DEVELOPMENT OF BIOSIMILARS IN BRAZIL

Development of Biosimilars in Brazil

This article presents a brief overview of the biosimilar industry in Brazil and in the world.Biosimilars are drugs originating from therapeutic or biological proteins, whose patents are expired or are going to expire.Similarly to the generic pharmaceutical industry, the expiration of patents for biologics allows the emergence of a new segment in th

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Comprehensive analysis of H3K27me3 LOCKs under different DNA methylation contexts reveal epigenetic redistribution in tumorigenesis

Abstract Background Histone modification H3K27me3 plays a critical role in normal development and is associated with various diseases, including cancer.This modification forms large chromatin domains, known as Large Organized Chromatin Lysine Domains (LOCKs), which span several hundred kilobases.Result In this study, we identify and categorize H3K2

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Ballistic Limit of High-Strength Steel and Al7075-T6 Multi-Layered Plates Under 7.62-mm Armour Piercing Projectile Impact

Abstract This paper presents the computational-based ballistic limit of laminated metal panels comprised of high strength steel and aluminium alloy Al7075-T6 plate at different thickness combinations to necessitate the weight reduction of existing armour steel plate.The numerical models of monolithic configuration, double-layered configuration and

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